Preformed donor-directed anti-HLA-DP antibodies may be an impediment to successful kidney transplantation
نویسندگان
چکیده
منابع مشابه
Preformed donor-directed anti-HLA-DP antibodies may be an impediment to successful kidney transplantation.
Recent reports have suggested an association of antiDP antibodies with allograft rejection and graft loss, in both primary kidney transplant recipients and in re-grafts [1–3]. However, in most cases, it is difficult to separate the effects of anti-HLA-DP antibodies from other anti-HLA class I and class II antibodies. Among non-conserved haplotypes, HLA-DP allele mismatches occur despite matchin...
متن کاملSuccessful kidney transplantation after desensitization in a patient with positive flow crossmatching and donor-specific anti-HLA-DP antibody
BACKGROUND Traditionally, the presence of antibodies against human leukocyte antigen (HLA)-C and DP was considered to be associated with only a low risk of antibody-mediated rejection (ABMR) in kidney transplantation (KT), because the antigenicities of these proteins are weak. However, the clinical effects of HLA-C and -DP donor-specific HLA antibodies (DSHAs) have recently been reevaluated. ...
متن کاملAnti-HLA Antibodies and Kidney Allograft Outcomes in Recipients with Donor Bone Marrow Cell Infusion
Background: Anti-HLA-antibodies are known to affect the allograft survival in transplant recipient patients. Objective: The aim of this study was to evaluate the association between anti-HLA antibodies and kidney allograft outcomes, particularly in recipients with concur-rent donor bone marrow cell infusion (DBMI). Methods: Between June 2006 and May 2007, forty living unrelated donor kidney tra...
متن کاملSuccessful living donor kidney transplantation across HLA and ABO incompatibilities.
A 56-year-old white female presented for evaluation for kidney transplantation in November 2003. Her end-stage renal disease (ESRD) was presumed due to medullary sponge kidney associated with stones and infection and she had started haemodialysis in April 2003. Other medical history included hypertension and anaemia. She was otherwise well. She had had four pregnancies and had received blood tr...
متن کاملPreexisting donor-specific HLA antibodies predict outcome in kidney transplantation.
The clinical importance of preexisting HLA antibodies at the time of transplantation, identified by contemporary techniques, is not well understood. We conducted an observational study analyzing the association between preexisting donor-specific HLA antibodies (HLA-DSA) and incidence of acute antibody-mediated rejection (AMR) and survival of patients and grafts among 402 consecutive deceased-do...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2007
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfm703